Sure, Freddy’s has psychotic murderous animatronics but the pizza is pretty damn good.
Well the entire season 3 finale of Legend of Korra fucked me up, so I’m gonna go cry in a corner for the rest of the day…
Crazy Ideas That Just Need to Happen Already
I’m shocked that some of these don’t already exist…
NASA just announced that they’re going to be launching the earth into space
We’ve come so far. Science is incredible
I have a crush on all the Chris’s ATM.
In an environment where others struggle to survive, Tibetans thrive in the thin air on the Tibetan Plateau, with an average elevation of 14,800 feet. A University of Utah led discovery that hinged as much on strides in cultural diplomacy as on scientific advancements, is the first to identify a genetic variation, or mutation, that contributes to the adaptation, and to reveal how it works. The research appears online in the journal Nature Genetics on Aug. 17, 2014.
“These findings help us understand the unique aspects of Tibetan adaptation to high altitudes, and to better understand human evolution,” said Josef Prchal, M.D., senior author and University of Utah professor of internal medicine.
For his research, Prchal needed Tibetans to donate blood, from which he could extract their DNA, a task that turned out to be more difficult than he ever imagined. It took several trips to Asia, meeting with Chinese officials and representatives of exiled Tibetans in India, to get the necessary permissions to recruit subjects for the study. But he quickly learned that official documents would not be enough. Wary of foreigners, the Tibetans refused to participate.
To earn the Tibetans’ trust, Prchal obtained a letter of support from the Tibetan spiritual leader, the Dalai Lama. “The Dalai Lama felt that a better understanding of the adaptation would be helpful not only to the Tibetan community but also to humanity at large,” said Prchal. He also enlisted the help of native Tibetan Tsewang Tashi, M.D., an author and clinical fellow at the Huntsman Cancer Institute at the University of Utah. More than 90 Tibetans, both from the U.S. and abroad, volunteered for the study.
Published in Science in 2010, Prchal’s group was the first to establish that there was a genetic basis to Tibetan high altitude adaptation. In the intervening years, first author Felipe Lorenzo, M.D., Ph.D., pioneered new techniques to tease out the secret to one of the adaptations from a “GC-rich” region of the Tibetans’ DNA that was particularly difficult to penetrate.
Their efforts were worth it; the DNA had a fascinating story to tell. About 8,000 years ago, the gene EGLN1 changed by a single DNA base pair. Today, a relatively short time later on the scale of human history, the vast majority of Tibetans – 88 percent - have the genetic variation, and it is virtually absent from closely related lowland Asians. The findings indicate the tiny genetic change endows its carriers with a selective advantage.
Prchal collaborated with experts throughout the world, including co-senior author Peppi Koivunen, Ph.D., from Biocenter Oulu in Finland, to determine that the newly identified genetic variation protects Tibetans by decreasing an aversive over-response to low oxygen. In those without the adaptation, the thin air causes their blood to become thick with oxygen-carrying red blood cells, often causing long-term complications such as heart failure. The EGLN1 variation, together with other unidentified genetic changes, collectively support life at high altitudes.
Prchal says the research also has broader implications. Because oxygen plays a central role in human physiology and disease, a deep understanding of how high altitude adaptations work may lead to novel treatments for various conditions, including cancer. “There is much more that needs to be done, and this is just the beginning,” he said.
When traveling with Tashi in Asia, Prchal was surprised at how he was able to get Tibetans to grasp the research they were being asked to take part in. Tashi simply helped them realize that their ability to adapt to life at high altitude was unique. “They usually responded by a little initial surprise quickly followed by agreement,” said Tashi. “It was as if I made them realize something new, which only then became obvious.”
Listen to an interview with Josef Prchal, Tsewang Tashi, and Felipe Lorenzo on The Scope Radio.
Homestuck troll skirt
I AM GOING TO FUCKING BUY A BLACK PLEATED SKIRT, SOME FUCKING HIGH-END-AS-SHIT FABRIC PAINT AND A TINY-ASS PRECISION PAINTBRUSH
THIS. WILL. BE. MINE.
THE BEGINNINGS OF KAWAII
No, no, you have no idea. It actually IS the beginning of the whole so-called “kawaii culture”. And it started because girls started using mechanical pencils, which provided fine handwriting. After being banished (more precisely, during the 80s), this kind of writing started being used in products like magazines and make-up. And, during this time, icons we usually associate with the whole kawaii industry (like the characters from Sanrio) came to life too.
And what many people don’t realize is that this subculture was born as a way for young girls to express themselves in their own way. And it was also used as something against the adult life and the traditional culture, often seen as dull and boring and oppressive. By embracing cuteness, these young girls (and adult women, after a while) were showing non-conformation with the current standards.
So yep. Kawaii is important, and it all started with cute, simple handwritting a few hearts and cat faces in some girls’ school notebooks <3
NO OK THIS IS SO IMPORTANT!
This is also how the kawaii fashions started! Girls began dressing in cute and off beat styles for themsleves, they were criticized by adult figures telling them “you’ll never find a husband if you dress that way!” to which they began to reply “Good!”
All the japanese subcultures and fashions that evolved out of this became a rebellion to tradition and the starch gender roles and expectations the adults were forcing on the younger generations. As early as the 70s and still to this day you’ll see an emphasis on child-like fashion and themes in more kawaii styles and the dismissal of the male gaze with styles like lolita (a lot of western people assume lolita is somehow sexual due to the name of the fashion, but ask any japanese lolita and they will tell you that men hate the style and find it unattractive which is sometimes a large reason they gravitate towards the style - they can express their femininity and individuality while remaining independent and without the pressure to appeal to men)
Its so so so important to understand the hyper cute and ‘odd’ fashions of Japanese girls carry such a huge message of feminism and reclaiming of their own lives.
so are you telling me that Japan’s punk phase was really the kawaii phase
So does that mean Avril Lavigne is done with her punk rock phase and going through a kawaii phase?
we need to sacrifice somebody so Ellen never dies
This is quickly becoming the Hunger Games for douchebags
THE 1ST ANNUAL DOUCHEBAG GAMES.
Hosted by Ellen
An ice bucket challenge. Mine. In a novelty bowtie. On the beach. With Death…